Cancer Cell Line Encyclopedia Nature

A compilation of gene expression chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines.

Cancer cell line encyclopedia nature. The ccle cancer cell line encyclopedia project is a collaboration between the broad institute and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models to develop integrated computational analyses that link distinct pharmacologic. The cancer cell line encyclopedia presents the first results from a large scale screen of some 947 cancer cell lines with 24 anticancer drugs with the aim of identifying specific genomic. Citation s barretina j et al. The cancer cell line encyclopedia is a database of gene expression genotype and drug sensitivity data for human cancer cell lines.

2012 the cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Quantitative proteomes of 375 cancer cell lines for the cancer cell line encyclopedia ccle reveal correlated protein expression between multiple pathways and complexes as well as associations between protein complexes and genetic features including microsatellite instability individual gene mutations and sensitivity to gene knockdowns.